The pathogenesis of diabetes retinopathy:progress in miRNAs
10.13389/j.cnki.rao.2024.0048
- VernacularTitle:糖尿病性视网膜病变的发病机制:miRNAs研究进展
- Author:
Tong LIU
1
;
Songdi WU
Author Information
1. 710002 陕西省西安市,西北大学附属第一医院(西安市第一医院)神经眼科;710002 陕西省西安市,西安市神经免疫疾病创新转化重点实验室
- Keywords:
diabetic retinopathy;
microRNAs;
diabetes
- From:
Recent Advances in Ophthalmology
2024;44(3):244-247
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy,a main microvascular complication of diabetes,remains the leading cause of blindness in the working-age population,but its specific pathogenesis has not been fully elucidated.microRNAs(miRNAs)are small non-coding RNAs,acting as post-transcriptional regulators of gene expression.Its aberrant expression plays a key role in modulating pathological processes associated to many diseases.Studies confirmed the role of miRNAs in the regulation of oxidative stress,inflammation,cell death and angiogenesis which influences the development of DR.This review focuses on the role of miRNAs in DR,which may provide a reference basis for diagnosis,prognosis and therapeutics.
