Molecular typing and precise treatment strategies for colorectal cancer: from experience to precision
10.3760/cma.j.cn115610-20230912-00088
- VernacularTitle:结直肠癌的分子分型与精准治疗策略：从经验到精确
- Author:
Minhua ZHENG
1
;
Sen ZHANG
;
Junjun MA
Author Information
1. 上海交通大学医学院附属瑞金医院普通外科 胃肠外科，上海市微创外科临床医学中心，上海 200025
- Keywords:
Colon neoplasms;
Rectal neoplasms;
Precision surgery;
Laparoscopy;
Sur-gical instrutments
- From:
Chinese Journal of Digestive Surgery
2023;22(10):1155-1159
- CountryChina
- Language:Chinese
-
Abstract:
Represented by colorectal cancer, gastrointestinal malignancies have unique clinical characteristics and biological behaviors, ranking high in the incidence and mortality rates in China. In recent years, with technological innovations and continuous optimization of disease management models, the concept of "precision surgery" has been driving the transformation of colorectal cancer surgery from traditional empirical surgical paradigms to modern precision surgical paradigms. Rapid advancements have been made in colorectal surgical treatment, including surgical techniques, instrument platforms, various novel targeted therapies, and immune combination therapies, which have demonstrated significant efficacy in colorectal cancer treatment. Meanwhile, with 30 years of development in laparoscopic colorectal surgery in China, the surgical approach for colorectal cancer has shifted from traditional open-bellied surgery to minimally invasive surgery. The diagnostic and therapeutic models for colorectal cancer patients have gradually transitioned from experience-driven to precision-based and individualized care. Guided by the concept of "precision surgery", this article combines the current status and trends in colorectal cancer surgery to discuss relevant molecular subtyping and precision treatment strategies, aiming to promote precise surgery and comprehensive treatment for colorectal cancer.
