The influencing factors of particle formation during the configuration of rifampicin for injection were investigated
10.3969/j.issn.1671-332X.2023.12.042
- VernacularTitle:考察注射用利福平配置过程产生微粒的影响因素
- Author:
Huaying HUANAG
1
;
Xiaojing YE
;
Lixiu LIU
;
Honglan ZHONG
;
Zicong ZHAO
Author Information
1. 广州市胸科医院//广州市结核病研究重点实验室 广东广州 510095
- Keywords:
Rifampicin for injection;
Stability test;
A fine particle;
PH value
- From:
Modern Hospital
2023;23(12):1965-1968
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of infusion particles and PH value of rifampicin for injection under dif-ferent configuration and application conditions,and to provide the best configuration method and the best infusion quality control strategy for rifampicin for injection.Methods The particle number and PH value of rifampin for injection were investigated and measured under different configuration and application conditions,and the factors affecting the formation of particles were ana-lyzed.Results The stable pH value of Rifampicin for injection was 7.2-8.1,and the number of particles was the least in the light filtering and 5%glucose 500 mL,and the number of particles was the least in 1～4 h after the configuration.Conclusion The optimal infusion quality control strategy is to filter rifampicin for injection by blocking light,500 mL of solute 5%glucose,1～4 h after configuration,and use of disposable precision filter infusion set.
