Application Progress of Hematopoietic Stem Cell Transplantation in Crohn's Disease
10.3969/j.issn.1008-7125.2023.08.006
- VernacularTitle:造血干细胞移植在克罗恩病中的应用进展
- Author:
Huagang WANG
1
;
Qi ZHOU
Author Information
1. 华中科技大学同济医学院附属同济医院消化内科(430030)
- Keywords:
Crohn's Disease;
Hematopoietic Stem Cell;
Transplantation
- From:
Chinese Journal of Gastroenterology
2023;28(8):489-494
- CountryChina
- Language:Chinese
-
Abstract:
Crohn's disease(CD)is a chronic,recurrent,and difficult-to-cure inflammatory disease of intestine.Currently,there is no cure for CD,and the mainstream therapy is oral or injectable immunosuppressants,such as 5-aminosalicylic acid(5-ASA),glucocorticoids,immunosuppressants,and biologics.However,with the extension of treatment time,many patients are intolerant to immunosuppressors or lose response,also lose the opportunity for surgery.The pathogenesis,progression and prognosis of CD are closely related to immune disorders,which makes it possible for hematopoietic stem cell transplantation(HSCT)to be applied in the treatment of CD.Due to the high incidence of adverse reactions,high recurrence rate,and even fatality,HSCT is not recommended for the initial treatment of CD,but is more suitable for patients with ineffective multi-drug treatment and lost the opportunity for surgery or patients with hematological system diseases or autoimmune diseases.It can be used as a clinical remedial treatment.
