Research Progress on the Mechanism of Type H Blood Vessels Promoting Angiogenesis-osteogenesis Coupling in Fracture Healing
10.3870/j.issn.1672-0741.23.07.009
- VernacularTitle:H型血管促进成血管-成骨耦联在骨折愈合中作用机制的研究进展
- Author:
Chengyin LU
1
;
Zhiqiang LUO
;
Gonghui JIAN
Author Information
1. 湖南中医药大学第二附属医院骨伤科,长沙 410005;湖南中医药大学第二中医临床医学院,长沙 410005
- Keywords:
type H blood vessel;
fracture;
angiogenesis;
osteogenesis;
angiogenesis-osteogenesis coupling
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(1):133-139
- CountryChina
- Language:Chinese
-
Abstract:
Fracture is a common orthopedic disease in clinical practice,and the resulting nonunion or delayed union of frac-tures is a major challenge in clinical treatment.In the process of fracture healing,there is a complex interaction between angio-genesis and osteogenesis,which is called the"angiogenesis-osteogenesis coupling"mechanism.In recent years,a new capillary subtype characterized by high expression of platelet endothelial cell adhesion molecule-1(PECAM-1/CD31)and salivary glyco-protein(EMCN),namely type H blood vessel,has been identified and found to play an important role in regulation of the angio-genesis-osteogenesis coupling.In this review,the mechanism of type H blood vessels promoting angiogenesis-osteogenesis cou-pling,the related molecules and signal pathways regulating type H blood vessels regeneration were discussed,in order to provide new ideas and methods for promoting fracture healing.
