Current research status and application prospects of S1P in asthma

VernacularTitle:S1P在哮喘中的研究现状及应用前景
Author: Chen YUAN ¹ ; Xia ZHAO ; Jiabao WU ; Hua YAN
Author Information

1. 南京中医药大学附属医院(南京 210029)
Keywords: sphingosine-1-phosphate; asthma; mechanism; clinical application; biomarker
From: The Journal of Practical Medicine 2024;40(7):936-940
CountryChina
Language:Chinese
Abstract: Asthma is a chronic inflammatory airway disease,and airway inflammation,airway hyper-respon-siveness and airway remodeling are the major pathological alterations in asthma.Numerous studies have demon-strated sphingosine metabolism disorders exist in asthma patients,and sphingosine-1-phosphate(S1P)is the end product of sphingolipid metabolism,which has become the focus of research as an important mediator of immune and inflammatory diseases,and is closely related to the development of asthma.In this paper,we summarize the role of S1P in the pathological changes of asthma from the relationship between S1P and asthma as well as its application in the clinical diagnosis,treatment and efficacy assessment of asthma,with a view to exploring more directions in the diagnosis and treatment of asthma.