The role and mechanism of purinergic signaling in oligodendrocytes development and myelin repair:A literature review
10.3969/j.issn.1006-5725.2024.05.021
- VernacularTitle:嘌呤能信号在少突胶质细胞发育和髓鞘修复中的作用及机制研究进展
- Author:
Yuehua HE
1
;
Hua XIE
;
Lin XIAO
Author Information
1. 脑认知与教育科学教育部重点实验室,华南师范大学脑科学与康复医学研究院,广东省心理健康与认知科学重点实验室、心理应用研究中心(广州 510631)
- Keywords:
ATP;
purinergic receptor;
oligodendrocyte;
myelination;
myelin repair
- From:
The Journal of Practical Medicine
2024;40(5):714-720
- CountryChina
- Language:Chinese
-
Abstract:
Oligodendrocytes(OLs)play a crucial role in myelination during the development and repair of the central nervous system.ATP serves not only as an important signaling molecule involving in the intercellular com-munications,but also as an energetic molecule,with its purinergic receptor subtypes widely present in neurons and glial cells.These subtypes are composed of two purinergic receptors:P1 and P2:The former are primarily activated by adenosine,and the latter mainly by ATP,ADP,and UTP.The two receptors paly their respective role in various regions of the CNS under physiological or pathological conditions through distinct mechanisms.In this paper,we review recent literature on the roles and mechanisms of the purinergic receptors in OL development,myelination,and myelin repair.It may be of great significance for further understanding the role of purinergic signaling in demy-elinating diseases and myelin dysplasia and exploring potential therapeutic targets.
