Efficacy and safety of anlotinib monotherapy and combinated therapy in the treatment of advanced pheo-chromocytoma/paraganglioma
10.3969/j.issn.1006-5725.2023.23.014
- VernacularTitle:安罗替尼单药及联合方案治疗晚期嗜铬细胞瘤/副神经节瘤的疗效与安全性研究
- Author:
Xianda CHEN
1
;
Nan MA
;
Shengjie GUO
;
Zhenhua LIU
;
Kai YAO
Author Information
1. 中山大学肿瘤防治中心,华南恶性肿瘤防治全国重点实验室,广东省恶性肿瘤临床医学研究中心(广州 510060)
- Keywords:
anlotinib;
pheochromocytoma;
paraganglioma;
efficacy;
safety
- From:
The Journal of Practical Medicine
2023;39(23):3106-3110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of anlotinib monotherapy and combined therapy in patients with advanced pheochromocytoma/paraganglioma.Methods Nine patients with advanced pheochromo-cytoma/paraganglioma(PPGL)who were admitted to the Department of Urology,Sun Yat-sen University Cancer Center from January 2018 to June 2023 were collected.Patients were divided into four groups according to different treatments:anlotinib monotherapy group(3 patients),anlotinib combined with PD-1 monoclonal antibody immuno-therapy group(3 patients),anlotinib combined with immunotherapy and chemotherapy group(2 patients),and anlotinib combined with chemotherapy group(1 patients).The effectiveness and safety of different treatment regiments of anlotinib were analyzed.Results Objective response rate(ORR):(44%),Partial response(PR):(44%),Stable disease(SD):(44%),Progressive disease(PD):(11%),Disease control rate(DCR):(89%).The ORR of 2 patients with SDH gene mutation,SDHB and SDHD respectively,was 100%.Median overall survival time(OS)was 16.3 months(IQR:11.3～21.8 months).Median progression-free survival(PFS)was 16.3 months(IQR:9.8～20.8 months).There were 2 patients with adverse events grade≥3/4,all of which were hypertension.Conclusions Anlotinib monotherapy and combined therapy have preliminary efficacy and manageable safety in the treatment of advanced pheochromocytoma/paraganglioma.
