Research progress of circadian clock genes regulating stem cell differentiation
10.3969/j.issn.1001-3733.2024.02.020
- VernacularTitle:生物钟基因调控干细胞分化的研究进展
- Author:
Jianan ZHENG
1
;
Ping GONG
Author Information
1. 610041 成都,口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院种植科
- Keywords:
Circadian clock;
Stem cell;
Differentiation;
Regulation mechanism
- From:
Journal of Practical Stomatology
2024;40(2):270-276
- CountryChina
- Language:Chinese
-
Abstract:
Circadian clock exists widely in all kinds of organisms and regulates various physiological activities of organisms,which mainly depends on the rhythmic expression of circadian clock genes.Circadian clock genes play an important role in many physiologi-cal processes,which has been shown to be closely related to tissue regeneration.Stem cells are the focus of regenerative medicine,and the regulation of stem cells directed differentiation can achieve tissue repair and regeneration.Studies have shown that circadian clock genes are the key factors regulating stem cell differentiation,so targeting circadian clock genes shows certain therapeutic prospects.In this review,the research progress of the regulation of circadian clock genes in the differentiation of stem cells and their related mecha-nisms is introduced and analyzed to provide possible ideas for the future application of regenerative medicine.
