Evaluation of the Impact of Human Papillomavirus Infection on the Clinical Outcomes of Intra-Uterine Insemination in Infertile Women Based on Propensi-ty Score Matching Method
- VernacularTitle:基于倾向性评分匹配法评估不孕女性人乳头瘤病毒感染对宫腔内人工授精临床结局的影响
- Author:
Xiaoyan REN
1
;
Jing ZHOU
;
Jianlei HUANG
Author Information
1. 空军军医大学唐都医院妇产科生殖医学中心,陕西 西安 710038
- Keywords:
Human papillomavirus;
Intrauterine insemination;
Propensity score matching;
Pregnancy outcome
- From:
Journal of Practical Obstetrics and Gynecology
2024;40(3):219-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the impact of human papillomavirus(HPV)infection on the clinical outcomes of intrauterine insemination(IUI)in infertile women.Methods:The clinical data of 685 patients(1046 cycles)who underwent IUI treatment were retrospectively analyzed at Tangdu Hospital of Air Force Medical University from January 2019 to July 2021,including 554 cases of artificial insemination with husband sperm(AIH).According to HPV infection,patients were divided into two groups,HPV positive group and HPV negative group,propensity score matching(PSM,1 ∶ 2)was used for IUI(80 cases in HPV-positive group and 158 cases in HPV-negative group)and AIH(65 cases in HPV-positive group and 129 cases in HPV-negative group)treatment patients,and the clinical outcomes of these patients were compared respectively.Results:There was no statistically significant difference in clinical pregnancy rate,live birth rate,ectopic pregnancy rate,abortion rate,macrosomia birth rate,and low body weight birth rate between HPV-positive group and HPV-negative group after matching with IUI treat-ment patients(P>0.05).There was no statistically significant difference in clinical pregnancy rate,live birth rate,ectopic pregnancy rate,miscarriage rate,macrosomia birth rate,and low body weight birth rate between the HPV positive group and the HPV negative group after matching AIH treatment patients(P>0.05).Conclusions:HPV infection in infertile female may not affect the clinical outcomes of IUI patients.
