Case report of neonatal kaposiform hemangioendothelioma in the spinal canal and mediastinum with Kasabach-Merritt phenomenon
10.3760/cma.j.cn101070-20230327-00255
- VernacularTitle:新生儿纵隔及椎管内卡波西型血管内皮瘤伴卡梅现象1例
- Author:
Ting LI
1
;
Zhenjie CHEN
;
Chenmei ZHANG
Author Information
1. 浙江大学医学院附属儿童医院，国家儿童健康与疾病临床医学研究中心重症医学科，杭州 310052
- Keywords:
Kaposiform hemangioendothelioma;
Kasabach-Merritt phenomenon;
Spinal canal;
Mediastinum;
Infant, newborn
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(3):221-223
- CountryChina
- Language:Chinese
-
Abstract:
Clinical data of one patient diagnosed with kaposiform hemangioendothelioma (KHE) in the spinal canal and mediastinum at the Children′s Hospital, Zhejiang University School of Medicine in October 2022 were retrospectively analyzed.Additionally, a literature review on mediastinal KHE was performed to summarize prior clinical characteristics and treatments.The patient, a 25-day-old boy, presented with refractory thrombocytopenia.Multiple chest radiographs suggested significant widening of the mediastinum and atypical atelectasis in the left upper lung, and enhanced chest CT and magnetic resonance imaging suggested KHE.After cocktail therapy with Prednisolone, Vincristine and Sirolimus, platelets increased to normal, and coagulation function improved.After 3 months of follow-up, hematologic parameters were stable, the mass became smaller, and no side effects occurred.
