Advances in epigenetics of nonalcoholic fatty liver desease
10.3969/j.issn.1672-8467.2024.02.018
- VernacularTitle:非酒精性脂肪性肝病的表观遗传学研究进展
- Author:
Ya-Kun ZHANG
1
;
Bei-Li WANG
;
Wei GUO
Author Information
1. 复旦大学附属中山医院检验科 上海 200032
- Keywords:
nonalcoholic fatty liver disease(NAFLD);
epigenetics;
methylation;
histone modification;
miRNA;
m6A;
lncRNA
- From:
Fudan University Journal of Medical Sciences
2024;51(2):262-267
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease(NAFLD)is a metabolic liver disease that ranges from relatively benign hepatic steatosis to nonalcoholic steatohepatitis(NASH).NASH is characterized by persistent liver damage,inflammation,and fibrosis which significantly increases the risk of end-stage liver diseases,such as liver cirrhosis and hepatocellular carcinoma.The pathogenesis of NAFLD/NASH is not yet fully understood,but its recent epigenetic advances have provided new insights into the mechanisms of this disease.This review summarized recent progress in this area which has laid a solid foundation for elucidating the pathogenesis of NAFLD and provides potential targets for early detection,diagnosis,and treatment of this disease.
