Research progress on the molecular regulation mechanism and clinical value of hedgehog-interacting protein in tumor

VernacularTitle:人音猬因子相互作用蛋白在肿瘤中的分子调控机制及临床价值的研究进展
Author: An-Li JIN ¹ ; Wei GUO
Author Information

1. 复旦大学附属中山医院检验科上海 200032
Keywords: hedgehog-interacting protein(HHIP); Hedgehog(Hh)signaling pathway; tumor
From: Fudan University Journal of Medical Sciences 2024;51(1):115-118
CountryChina
Language:Chinese
Abstract: HHIP gene encoded human hedgehog-interacting protein,locating on chromosome 4q31.21-31.3.As an endogenous antagonist of Hedgehog(Hh)signaling pathway,HHIP inhibits the activation of Hh signaling pathway.In human cancers,the Hh signaling pathway has always been abnormally activated,and HHIP expression is generally down-regulated in most types of tumor tissues.The expression level of HHIP is positively correlated with overall survival of tumor patients,which is expected to be used as an independent prognostic marker.This review focused on the progress of HHIP research regarding its biological function,mechanism,and clinical value in tumor.