Effect of alendronate tablets combined with calcitonin therapy on IGF-1, PINP and S-CTX levels in patients with T2DM combined with osteoporosis
10.3760/cma.j.cn.115807-20230314-00072
- VernacularTitle:阿仑膦酸钠片联合降钙素治疗对T2DM合并骨质疏松患者对IGF-1、PINP和S-CTX水平的影响
- Author:
Lanxiang WEI
1
;
Yijun WANG
;
Wei XIONG
Author Information
1. 中国中医科学院西苑医院内分泌科，北京 100091
- Keywords:
Type 2 diabetes mellitus;
Osteoporosis;
Alendronate tablets;
Calcitonin
- From:
Chinese Journal of Endocrine Surgery
2023;17(5):554-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of combined treatment with alendronate tablets and calcitonin on insulin like growth factor-1 (IGF-1), procollagen type Ⅰ amino terminal lengthening peptide (PINP) and c-terminal telopeptide of type Ⅰ collagen (S-CTX) levels in patients with type 2 diabetes mellitus (T2DM) combined with osteoporosis (OP) .Methods:Using the principle of randomized controlled experiment, 130 patients in Xiyuan Hospital, China Academy of Chinese Medical Sciences from Feb. 2021 to Feb. 2022 were selected as study subjects and divided into control group and observation group according to the randomized envelope method in the ratio of 1:1, 65 cases each. The control group was treated with calcitonin and the observation group was treated with alendronate tablets combined with calcitonin, both were treated continuously for 6 months. The therapeutic effect, bone mineral density, blood glucose related indexes [fasting blood glucose (FPG), 2 h postmeal blood glucose (2 hPG), glycosylated hemoglobin content (HAb1c) ], 25 hydroxyvitamin D[25 (OH) D], IGF-1, PINP, S-CTX, and adverse reactions were statistically compared between the two groups.Results:The total effective rate of the observation group was 98.46%, higher than that of the control group 86.15% ( P < 0.05) ; After 6 months of treatment, the bone mineral density of left femoral neck, hip, lumbar spine L1-L4 and Wards triangle in the observation group was higher than that in the control group ( P < 0.05) ( P < 0.05) ; After 6 months of treatment, the levels of PINP (38.36 ± 3.44 vs 42.77 ± 3.86, t=6.88, P<0.001) and S-CTX (0.36 ± 0.13 vs 0.52 ± 0.13, t=7.02, P<0.001) in the observation group were lower than those in the control group, while the levels of 25 (OH) D (31.28 ± 5.96 vs 27.46± 5.18, t=3.90, P<0.001) and IGF-1 (167.82 ± 39.46 vs 150.86 ± 40.27, t=2.43, P=0.017) were higher than those in the control group; FPG, 2 hPG and HAb1c levels in the observation group were lower than those in the control group after 6 months of treatment ( P < 0.05) ; The difference was not statistically significant when comparing the incidence of adverse reactions between the two groups ( P>0.05) . Conclusion:The combined treatment of T2DM combined with osteoporosis with alendronate tablets sodium and osteopontin can further increase bone mineral density, regulate bone metabolism and improve osteoporosis symptoms, and also have a positive effect on blood glucose control.
