Expression of CXCR5 and its significance of clinical and pathological in classical Hodgkin lymphoma
10.13315/j.cnki.cjcep.2024.01.009
- VernacularTitle:经典型霍奇金淋巴瘤中CXCR5的表达及临床病理意义
- Author:
Zhixiong XIA
1
;
Xiaoge ZHOU
;
Yuanyuan ZHENG
;
Yanlin ZHANG
;
Jianlan XIE
Author Information
1. 首都医科大学附属北京友谊医院病理科,北京 100050;华中科技大学同济医学院附属武汉中心医院病理科,武汉 430010
- Keywords:
lymphoma;
classic Hodgkin lymphoma;
anaplastic large cell lymphoma;
CXCR5;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(1):35-39
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of Che-mokine(C-X-C Motif)receptor 5(CXCR5)and its clinico-pathological significance in classic Hodgkin lymphoma(CHL).Methods The expression of CXCR5 was assessed in 33 pa-tients by immunohistochemistry(IHC),and retrospectively ana-lyzed the expression and clinical significance of CXCR5 in the four subtypes of CHL.Meanwhile,10 cases of ALK-positive an-aplastic large cell lymphoma(ALCL)and 10 cases of ALK-neg-ative ALCL were collected as the control group.ResultsThere were 31 cases with CXCR5-positive in all 33 cases(93.94％),including 15/16(93.75％)in nodular sclerosis CHL,12/13(92.31％)in mixed cellularity CHL,2/2 in lymphocyte-rich CHL,and 2/2 in lymphocyte-depleted CHL.The positive ex-pressions of CXCR5 in different immunophenotypes of CHL were as follow,31/33(93.94％)in CD30 positive and PAX5 weakly positive CHL.12/14(85.71％)in CD15 negative CHL,24/26(92.31％)in CD20 negative CHL,10/11(90.91％)in EBER-negative CHL and 5/6 in LMP1-negative CHL.CXCR5 were not expressed in all 20 cases of ALCL.Conclusion The positive expression rate of CXCR5 in CHL is high.When the tumor cells are negative for CD15,LMP1 and CD20 or EBER,CXCR5 also has a high positive expression rate,which is helpful for the diagnosis of CHL.CXCR5 can be used to differentiate CHL from ALCL,especially the cases lacking typical morpholo-gy and immunohistochemistry.
