Chemical Compounds Isolated from Dendrobium crepidatum and Their Bioactive Activities
10.12259/j.issn.2095-610X.S20231231
- VernacularTitle:玫瑰石斛的化学成分及其生物活性
- Author:
Chenxi ZHUANG
1
;
Huimin WANG
;
Yaping CHEN
;
Rui ZHANG
;
Jinrong ZHENG
;
Meihong LI
;
Yupeng LI
Author Information
1. 昆明医科大学药学院暨云南省天然药物药理重点实验室,云南 昆明 650500;红河卫生职业学院药学院,云南 红河 661100;昆明医科大学现代生物医药产业学院,云南 昆明 650500
- Keywords:
Dendrobium crepidatum;
Chemical constituents;
Bioactive activity
- From:
Journal of Kunming Medical University
2023;44(12):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the chemical constituents from the herbs of Dendrobium crepidatum and identify its antitumor bioactive compounds.Methods The constituents were extracted by methyl alcohol and isolated by CC and Sephadex LH-20.Their structures were identified by spectroscopic analysis(1H NMR,13CNMR and EIMS).The antitumor activity of the constituents was determined by MTT assay in vitro.Results 9 compouds were obtained and identified as p-hydroxybenzaldehyde(1),p-methoxyphenol(2),p-Hydroxybenzyl alcohol(3),hydroquinone(4),(24R)-ethylcholest-5-en-3-ol-7-one(5),sinalexin(6),bis(2-ethylhexyl)benzene-1,2-dicarboxylate(7),pinoresinol(8),Chaenomin B(9).The antitumor activity of compounds 5～9 was tested,and it was found that compound 9 had good inhibitory activity against A549 cell line.Conclusion Compounds 2～5,7～8 were isolated from the herbs for the first time and compounds 6,9 were isolated from this genus for the first time.IC50 of 9 on A549 cell line is 29.35 μM.
