Application progress of zebrafish(Danio rerio)model in circadian rhythm research
10.7644/j.issn.1674-9960.2024.01.013
- VernacularTitle:斑马鱼模型在昼夜节律研究中的应用进展
- Author:
Youjia ZONG
1
;
Yunong LI
;
Jiabin GUO
;
Hui PENG
Author Information
1. 解放军疾病预防控制中心,北京 100071;中国医科大学公共卫生学院,沈阳 110122
- Keywords:
circadian rhythm;
zebrafish;
clock gene;
behavioral response
- From:
Military Medical Sciences
2024;48(1):75-80
- CountryChina
- Language:Chinese
-
Abstract:
Circadian rhythm is one of the biorhythms formed by organisms in the process of evolution to adapt to the rotation of the earth,which is manifested as a cyclical biorhythm of about 24 hours produced by the body under the control of the internal biological clock,coordinating sleep/wakefulness,body temperature regulation,endocrine time and other activities.Long-term circadian rhythm disorders can cause increased risk of metabolic disorders,gastrointestinal diseases,neurodegenerative diseasesand other illnesses.As a typical model animal,the aquatic organism zebrafish(Danio rerio)has been widely used in experimental studies of circadian rhythm.This paper introduces in detailthe operating mechanism of zebrafish circadian clock,the influencing factors of the input system,the genes and pathways of the circadian clock,and the physiological output,summarizes the application and advantages in circadian rhythm research,finally looks forward to future research and development,in order to provide theoretical support for circadian rhythm regulation mechanism research,related drug development and disease treatment strategies.
