Research progress in the molecular biological mechanism of 125I seed in the treatment of malignant tumors
10.3969/j.issn.1008-794X.2023.12.020
- VernacularTitle:125I粒子治疗恶性肿瘤的分子生物学机制研究进展
- Author:
Chao WANG
1
;
Bai SUN
;
Hao WANG
;
Hongbing SHI
Author Information
1. 213003 江苏常州 常州市第一人民医院肿瘤科
- Keywords:
125I seed;
malignant tumor;
molecular biology
- From:
Journal of Interventional Radiology
2023;32(12):1263-1268
- CountryChina
- Language:Chinese
-
Abstract:
Interstitial implantation of 125I seeds is a kind of continuous low-dose-rate internal irradiation therapy,and it has been used in the treatment of various malignant tumors.In recent years,molecular biology research on the treatment of malignant tumors with 125I seeds has been gradually carried out and deepened.In addition to damaging DNA,125I seeds also act on the endoplasmic reticulum and mitochondria,and then,through multiple signaling pathways,induce tumor cells apoptosis and paraptosis,promote cytoprotective autophagy,and inhibit epithelial-mesenchymal transition of tumor cells.Moreover,125I seeds can also improve the tumor microenvironment.125I seeds can suppress tumor growth by inhibiting tumor microvessels and activating the immune response.This paper reviews the above-mentioned biological effects and related molecular mechanisms induced by 125I seeds,aiming to provide ideas for future mechanism research and combination therapy.(J Intervent Radiol,2023,32:1263-1268)
