Neurobiology of N-glycosylation modification and its roles in neurological disorders
10.16098/j.issn.0529-1356.2024.02.017
- VernacularTitle:N-糖基化修饰的神经细胞生物学及其在神经系统疾病中的作用
- Author:
Ke-Xing XU
1
;
Meng-Xuan WANG
;
Xue-Kun LI
Author Information
1. 浙江大学医学院附属儿童医院遗传代谢科,国家儿童健康与疾病临床医学中心,杭州 310052;浙江大学医学院转化医学研究院,杭州 310029
- Keywords:
N-glycan;
N-glycosylation;
Neuron;
Glia;
Neuronal development;
Neurological disorder
- From:
Acta Anatomica Sinica
2024;55(2):241-246
- CountryChina
- Language:Chinese
-
Abstract:
Neurodevelopment and neuronal function are modulated by multiple factors including environment,genetics and epigenetics.As a post-translational modification,N-glycosylation is catalyzed by glycosyltransferase and involves in diverse biological processes.N-glycosylation is abundant in neuronal system,regulates the development and maturation of synapse,and inflammatory response of glial cells.The dysregulation of N-glycosylation induces neurological disorders including Alzheimer's disease,congenital disorders of glycosylation,schizophrenia and epilepsy.In the present review,we have summarized the progresses of N-glycosylation in regulating neuronal and astrocytic function,and its roles in neurological disorders and related mechanisms.
