Application and research progress of fecal microbiota transplantation in refractory diarrhea
10.11855/j.issn.0577-7402.0151.2023.0531
- VernacularTitle:粪菌移植在难治性腹泻中的应用进展
- Author:
Tong LI
1
;
Ning WANG
;
Xin WANG
Author Information
1. 西安医学院,陕西西安 710021;空军军医大学唐都医院消化内科,陕西西安 710038
- Keywords:
fecal microbiota transplantation;
intestinal flora;
refractory diarrhea
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(2):229-235
- CountryChina
- Language:Chinese
-
Abstract:
When refractory diarrhea comes on,it greatly affects the life and daily work of patients,and there is no unified treatment.Patients with refractory diarrhea have varying degrees of intestinal flora disorder,so rebuilding the intestinal micro ecosystem may be an effective way to treat refractory diarrhea.Fecal microbiota transplantation(FMT)has the potential to be an effective treatment for refractory diarrhea as a therapy that reconstructs normal intestinal flora.In recent years,FMT has been applied to the treatment of some refractory diarrhea related to intestinal flora imbalance,such as recurrent clostridium difficile infection,inflammatory bowel disease,irritable bowel syndrome,and has achieved good results,but some problems have not been properly solved so far.This article reviews the mechanism of action of FMT in the treatment of refractory diarrhea,its clinical application,research progress and current problems.
