Progress on effect of CypA/CD147 in diagnosis and treatment of cardiovascular system disease infected by SARS-CoV-2
10.11855/j.issn.0577-7402.0493.2023.0915
- VernacularTitle:CypA/CD147在SARS-CoV-2感染性心血管疾病诊疗中的作用研究进展
- Author:
Ming-Ren MA
1
;
Fei WANG
;
Xiao-Qing CAI
;
Yan LIU
;
Ling MA
Author Information
1. 解放军联勤保障部队第940医院心血管内科,甘肃兰州 730050
- Keywords:
cyclophilin A;
extracellular matrix metalloproteinase inducer;
severe acute respiratory syndrome coronavirus 2;
cardiovascular system;
cardiovascular diseases
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(1):115-120
- CountryChina
- Language:Chinese
-
Abstract:
Corona virus disease 2019(COVID-19)epidemic has been effectively controlled,but its related complications still cannot be ignored,especially the cardiovascular circulatory system is the active site of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Angiotensin-converting enzyme 2(ACE2)is a type Ⅰ transmembrane glycoprotein that is highly expressed in heart,kidney and testis.Spike protein of SARS-CoV-2 invades host cells by binding to the cell surface receptor ACE2.However,there are still many deficiencies in the clinical application of vaccines and drugs developed based on this target.As a molecular chaperone,cyclophilin A(CypA)promotes protein folding and T cell activation.CD147 is one of the most widely studied CypA receptors,and the interaction of CypA/CD147 plays an important role in the entry of SARS-CoV-2 into host cells.However,there are few reports on the invasion of SARS-CoV-2 into the cardiovascular system through the CypA/CD147 signaling pathway.Based on this,this article summarizes the previous research evidence and the research basis of the research group,and reviews the structure and function of CypA/CD147,the role of CypA/CD147 in cardiovascular disease,and the cardiovascular disease caused by SARS-CoV-2 targeting CypA/CD147 signal pathway,in order to provide reference for the diagnosis and treatment of the COVID-19 complicated with cardiovascular system diseases.
