Research progress of metabolomics in the diagnosis and treatment of severe injuries

VernacularTitle:代谢组学在重伤诊治中的研究进展
Author: Bin WEI ¹ ; Hongjie DUAN ; Jiake CHAI
Author Information

1. 中国人民解放军总医院第四医学中心烧伤整形医学部,北京 100048;中国人民武装警察部队北京总队医院外一科,北京 100027
Keywords: metabolomics; trauma; burn; burn-blast combined injury
From: Basic & Clinical Medicine 2024;44(4):562-567
CountryChina
Language:Chinese
Abstract: Metabolomics is a novel emerging technology recently applied in management of severe diseases and trauma,and has been widely used in gene analysis of disease metabolic disorders,clinical biomarker screening and disease diagnosis.This review comprehensively summarizes the latest research progress of the metabolomics in severe trauma and burns recently like traumatic brain injury(TBI),traumatic hemorrhagic shock,severe burns and so on.The paper elaborates the metabolomic technology which can quickly reflect the real-time metabolic changes of severely injured patients at different stages after injury,and uncovers new clinical biomarkers and potential drug targets of the patients with severe injuries thus improves the diagnosis and treatment strategies.Finally,we look for-ward to the current metabolomics research projects and tackling challenges on the burn-blast combined injuries,and the simultaneous development of multi-omics technology as well as artificial intelligence algorithms,which promotes the development of precision medicine.