Intensive phototherapy don't affect cellular immune function and short-term reactions after discharge in neonatal hyperbilirubinemia
10.16352/j.issn.1001-6325.2024.03.0379
- VernacularTitle:强光疗不影响高胆红素血症新生儿细胞免疫功能及出院后近期免疫反应
- Author:
Zhen LIU
1
;
Dalian WANG
;
Jie ZHANG
;
Qixing ZHANG
;
Fei WANG
Author Information
1. 复旦大学附属上海市第五人民医院 儿科,上海 200240
- Keywords:
hyperbilirubinemia;
intensive phototherapy;
neonate;
cellular immunity;
adverse reaction
- From:
Basic & Clinical Medicine
2024;44(3):379-383
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of intensive phototherapy for neonatal hyperbilirubinemia on cellular immune function and short-term immune-related adverse effects.Methods Totally 180 infants with hyperbilirubi-nemia were treated with different light intensity,the efficacy,cellular immune function and immune adverse effects were followed up for six months after discharge.Results After phototherapy,serum interleukin-6(IL-6)in both groups were decreased and CD4+(%)and CD4+/CD8+were increased than that before phototherapy.The decrease rate of total bilirubin in the intensive phototherapy group was significantly faster than that in the conventional photo-therapy group,at the same time,the total duration of phototherapy and hospital stay were significantly shorter than that in the conventional phototherapy group(P＜0.05).No statistical significance in the incidence of diarrhea,rash,fever and hypo-calcemia during hospitalization and no immune-related adverse effects in 6 months after discharge were recorded.Conclusions Compared with conventional phototherapy,intensive phototherapy reduces serum bilirubin level more quickly and shorten the duration of phototherapy and hospital stay.No common adverse effects nor immune-related adverse effects are recorded during hospitalization and the period of six months after discharge.
