Progress of research on role of lipotoxicity in pathogenesis of sarcopenia
10.16352/j.issn.1001-6325.2023.12.1886
- VernacularTitle:脂毒性在肌少症发生发展中作用的研究进展
- Author:
Qi JIANG
1
;
Liu YANG
;
Jiaojiao HE
;
Weixin LI
Author Information
1. 兰州大学 第一临床医学院,甘肃 兰州 730000
- Keywords:
free fatty acids;
lipotoxicity;
sarcopenia;
pathogenesis
- From:
Basic & Clinical Medicine
2023;43(12):1886-1890
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia is a serious health concern that must be payed attention by aged people.The occurrence of sarcopenia in obese older individuals may be intricately linked to lipotoxic substances such as free fatty acids(FFA),diacylglycerols(DAG),and ceramides,which are toxic to skeletal muscle cells.Lipotoxic substances in-duce inflammatory responses,oxidative stress,endoplasmic reticulum stress,and insulin resistance in skeletal mus-cle cells,disrupting protein metabolism and impairing regeneration and then lead to the onset of sarcopenia.Up to the present,the precise mechanisms by which lipotoxicity in skeletal muscle results in the development of sarcope-nia remain incompletely understood.Further research may highlight the orientation for the prevention and treatment of sarcopenia.
