Research progress of microRNAs suppressing tumorigenesis through Hippo signaling
10.16352/j.issn.1001-6325.2023.12.1871
- VernacularTitle:microRNAs通过Hippo通路抑制肝细胞癌发生的研究进展
- Author:
Na CHA
1
;
Dandan HAO
;
Tianzhu LI
Author Information
1. 赤峰学院附属医院 肿瘤内科,内蒙古 赤峰 024000
- Keywords:
hepatocellular carcinoma;
Hippo pathway;
microRNAs;
molecular mechanism
- From:
Basic & Clinical Medicine
2023;43(12):1871-1875
- CountryChina
- Language:Chinese
-
Abstract:
The aberrant activation of yes-associated protein(YAP)and transcriptional coactivator with PDZ-bind-ing motif(TAZ),downstream effectors of the Hippo signaling pathway,has been implicated in hepatocellular carcinoma(HCC).The microRNAs(miRNAs)works as a tumor suppressors that influence the proliferation,migration and apoptosis of tumor cells by modulating Hippo-YAP/TAZ signaling during hepatic tumorigenesis.Exploring the role of miRNAs in regulating Hippo YAP/TAZ pathway in HCC can provide new ideas for the diag-nosis and treatment of HCC.
