Research progress on the role of MTAP in malignant mesothelioma
10.3760/cma.j.cn371439-20231109-00014
- VernacularTitle:MTAP基因在恶性间皮瘤中的研究进展
- Author:
Xudong JIN
1
;
Zhongjian CHEN
;
Weimin MAO
Author Information
1. 温州医科大学研究生培养基地（浙江省肿瘤医院），杭州 310022
- Keywords:
Methylthioadenosine phosphorylase;
Malignant mesothelioma;
Diagnosis, differential;
Drug therapy;
Prognosis
- From:
Journal of International Oncology
2024;51(2):99-104
- CountryChina
- Language:Chinese
-
Abstract:
Methylthioadenosine phosphorylase (MTAP) is a rate-limiting enzyme in the methionine and purine salvage pathway, and is closely related to polyamine metabolism, adenine metabolism and methionine metabolism. MTAP is frequently deleted in malignant mesothelioma (MM) and plays an important role in the diagnosis and differential diagnosis of MM. At the same time, metabolic reprogramming caused by MTAP deletion creates new therapeutic strategies for MM. Besides, MTAP gene is also associated with the prognosis of MM, therefore MTAP is a significant biomarker for the diagnosis, treatment and prognosis of MM.
