Senotherapies in cancers
10.3760/cma.j.cn371439-20230606-00138
- VernacularTitle:肿瘤的衰老治疗
- Author:
Hongyun YUE
1
;
Baihong ZHANG
Author Information
1. 中国人民解放军联勤保障部队第九四〇医院眼科，兰州 730050
- Keywords:
Neoplasms;
Cellular senescence;
Therapy
- From:
Journal of International Oncology
2023;50(12):734-738
- CountryChina
- Language:Chinese
-
Abstract:
Cancer cells have a senescence response, and senescence in cancer cells have both tumor-suppressive and tumor-promoting effects. Cancer senotherpy includes pro-senescent cancer therapy, senolytic therapy and senomorphic therapy. However, the efficacy and adverse effects need to be thoroughly studied. Detection of senescence-associated proteins and metabolites within the patients' cancer senescent cells and peripheral blood may help to evaluate the efficacy of senotherapy and guide future clinical trials.
