Research progress of memantine hydrochloride in the treatment of radiation-induced cognitive dysfunction and its combined application with vitamins

VernacularTitle:盐酸美金刚治疗放射性认知功能障碍及其与维生素联合应用的研究进展
Author: Jin WANG ¹ ; Ruoyang LI ; Xuewei ZHAO ; Hui LI ; Zhiguo ZHOU ; Jingxia ZHAO
Author Information

1. 河北医科大学研究生院，石家庄　050011
Keywords: Radiotherapy; Cognitive dysfunction; Memantine; Vitamins
From: Journal of International Oncology 2023;50(10):622-626
CountryChina
Language:Chinese
Abstract: Radiation-induced cognitive dysfunction (RICD) has an insidious onset and there is a lack of effective prevention and treatment measures. The efficacy of memantine hydrochloride as a classical treatment drug is limited, and it is inevitable to seek multi-target combination drugs. In recent years, the protective effect of vitamin E and vitamin D on cognitive function has been widely recognized. Several basic studies have shown that vitamin E can play a role in the combination of medication by protecting neurons and reducing the adverse effects caused by memantine hydrochloride; Vitamin D and memantine hydrochloride have also become a hot topic of research due to their significant synergistic effects. The combination of memantine hydrochloride and vitamin therapy is expected to bring additional benefits to RICD patients.