Research progress of NADPH oxidase 2 in malignant tumors
10.3760/cma.j.cn371439-20230428-00117
- VernacularTitle:NADPH氧化酶2在恶性肿瘤中的研究进展
- Author:
Xiaojie LIU
1
;
Junxing HUANG
Author Information
1. 南京医科大学附属泰州人民医院/泰州市人民医院肿瘤科，泰州 225300
- Keywords:
NADPH oxidase 2;
Neoplasms;
Reactive oxygen species;
Drug resistance, neoplasm;
Prognosis
- From:
Journal of International Oncology
2023;50(10):618-621
- CountryChina
- Language:Chinese
-
Abstract:
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2) acts as a source of reactive oxygen species, which participates in and influences normal physiological function of human body. Nowadays, many studies have found that Nox2 is related to prognosis of patients, drug resistance and molecular targeted therapy in various malignant tumors, such as acute myeloid leukemia, gastric cancer, colorectal cancer, ovarian cancer, lung cancer and esophageal cancer. What's more, it may be a novel biomarker and a potential therapeutic target for malignant tumors.
