Dickkopf-1: a potential therapeutic target for ischemic stroke
10.3760/cma.j.issn.1673-4165.2023.09.011
- VernacularTitle:Dickkopf-1：缺血性卒中的潜在治疗靶点
- Author:
Guorong CHAI
1
;
Meiyan CHEN
;
En XU
Author Information
1. 广州医科大学神经科学研究所，广州医科大学附属第二医院神经内科，广州 510260
- Keywords:
Stroke;
Cerebral ischemia;
β-catenin;
Wnt signal pathway;
Cell apoptosis;
Neurogenesis;
Biomarkers;
Dickkopf-1
- From:
International Journal of Cerebrovascular Diseases
2023;31(9):698-702
- CountryChina
- Language:Chinese
-
Abstract:
Dickkopf-1 (DKK1) is a secreted glycoprotein that acts as an inhibitor of the Wnt/β-catenin pathway and plays an important role in embryonic development, neurogenesis and synaptogenesis. After cerebral ischemia, DKK1 inhibits neurogenesis and angiogenesis by promoting neuronal apoptosis and blood-brain barrier damage, thus aggravating brain injury. In addition, serum DKK1 in patients with ischemic stroke was associated with different disease stages and outcomes. Therefore, the development of specific inhibitors targeting DKK1 is expected to be applied in the treatment of ischemic stroke.
