Risk factors for acute ischemic stroke in patients with lung cancer
10.3760/cma.j.issn.1673-4165.2023.06.004
- VernacularTitle:肺癌患者急性缺血性卒中的危险因素
- Author:
Pingping YANG
1
;
Yongbo ZHANG
Author Information
1. 首都医科大学附属北京友谊医院神经内科，北京 100050
- Keywords:
Ischemic stroke;
Lung neoplasms;
Risk factors;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2023;31(6):424-428
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors of acute ischemic stroke in patients with lung cancer.Methods:Patients with lung cancer admitted to Beijing Friendship Hospital, Capital Medical University from July 2019 to August 2021 were retrospectively included. The demographics and baseline clinical data of the patients were collected. According to whether acute ischemic stroke had occurred, the patients were divided into a case group and a control group.Results:According to the propensity matching score method, 26 patients with lung cancer were included in the case group and 104 in the control group. There were significant differences in age, tumor staging, metastasis and treatment of lung cancer, hypertension, diabetes, hyperlipidemia, atrial fibrillation, alcohol consumption, diastolic blood pressure, systolic blood pressure, hemoglobin, triglyceride and squamous cell carcinoma associated antigen (SCC) between the two groups (all P<0.05). Multivariate logistic regression analysis showed that older individuals (odds ratio [ OR] 1.087, 95% confidence interval [ CI] 1.063-1.211; P=0.007), lung cancer treatment ( OR 1.698, 95% CI 1.139-2.532; P=0.009), hypertension ( OR 5.647, 95% CI 1.921-16.597; P=0.002), diabetes ( OR 3.082, 95% CI 1.020-9.311; P=0.046), hyperlipidemia ( OR 5.163, 95% CI 1.020-9.311; P=0.002), atrial fibrillation ( OR 5.105, 95% CI 1.852-14.39; P=0.006), alcohol consumption ( OR 0.30, 95% CI 0.123-0.733; P=0.008), diastolic blood pressure ( OR 1.032, 95% CI 0.123-0.733; P=0.022), systolic blood pressure ( OR 1.032, 95% CI 1.003-1.061; P=0.031), hemoglobin ( OR 1.358, 95% CI 0.985-1.871; P=0.042), and SCC ( OR 1.535, 95% CI 1.069-2.204; P=0.02) were the independent risk factors for acute ischemic stroke in patients with lung cancer. Conclusions:Lung cancer related ischemic stroke is more common in elderly patients, and such patients have higher levels of hemoglobin, triglycerides, and SCC. Age, lung cancer treatment, common vascular risk factors, hemoglobin, and SCC are the potential risk factors for acute ischemic stroke in patients with lung cancer.
