Discussion on importance of reasonable range of sugar-to-fat ratio in parenteral nutrition prescriptions
10.16151/j.1007-810x.2023.05.001
- VernacularTitle:肠外营养处方糖脂比合理范围重要性探讨
- Author:
Jing-Xu NIE
1
;
Kai-Xia CUI
;
Xue-Yan QI
;
Zhi-Ying HAO
;
Lian-Zhen CHEN
Author Information
1. 山西省肿瘤医院/中国医学科学院肿瘤医院山西医院/山西医科大学附属肿瘤医院药学部,山西太原 030000
- Keywords:
Parenteral nutrition;
Sugar-to-fat ratio;
Rational use
- From:
Parenteral & Enteral Nutrition
2023;30(5):257-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the medication safety issues caused by unreasonable sugar-to-fat ratio in clinical practice of parenteral nutrition,providing a basis for the rational use of clinical nutritional drugs.Methods:From the beginning of the database construction until February 28,2023,relevant databases at home and abroad were searched to summarize and analyze the clinical adverse outcomes caused by unreasonable sugar-to-fat ratio prescriptions encountered in the included literature and clinical practice.Results:Eleven articles were included,and 1 case of patient discomfort was improved by adjusting the unreasonable sugar-to-fat ratio.A total of 86 patients were involved,including 51 males and 35 females,with an age range of 18 to 89 years.Among the 86 patients,there were 79 clinical adverse outcomes,including 8 deaths.The incidence rates of clinical adverse outcomes were as follows:abnormal liver function 46.8％(37/79),bile stasis 22.8％(18/79),fat overload syndrome 13.9％(11/79),liver steatosis 11.4％(9/79),platelet reduction 3.8％(3/79),and other 1.3％(1/79).Among the 86 patients,2 cases were clearly recorded to have improved clinical adverse outcomes after adjusting the sugar-to-fat ratio,and the others were not detailed.Conclusions:Inappropriate sugar-to-fat ratio may lead to safety issues related to parenteral nutrition medication and should be given clinical attention.
