Correlation between anti-leukemia effect of scutellaria baicalensis Georgi and regulation of bone marrow microenvironment
10.3760/cma.j.cn115356-20220704-00191
- VernacularTitle:黄芩抗白血病作用与调控骨髓微环境的相关性研究
- Author:
Lin BO
1
;
Tao WEN
;
Ruihua ZHANG
;
Haiying LI
Author Information
1. 甘肃中医药大学公共卫生学院，兰州 730000
- Keywords:
Scutellaria baicalensis;
Bone marrow microenvironment;
Leukemia
- From:
Journal of Leukemia & Lymphoma
2023;32(10):631-634
- CountryChina
- Language:Chinese
-
Abstract:
Scutellaria baicalensis Georgi, one of the commonly used Chinese herbal medicines in clinic, has a variety of chemical components, mainly flavonoids, including baicalein, baicalin, wogonin. And its pharmacological effects include anti-tumor, antibacterial, antiviral, and antioxidant. The bone marrow microenvironment is a complex network structure composed of mesenchymal stem cells, hematopoietic stem cells, extracellular matrix and various soluble factors. Its malignant transformation affects the development and progression of hematological diseases such as leukemia. Studies have found that scutellaria baicalensis Georgi can act on various components of the bone marrow microenvironment. By influencing related signal transduction pathways, cytokines, apoptosis pathways and energy metabolism pathways, the development and progression of leukemia and multidrug resistance are regulated. This review summarizes the correlation of scutellaria baicalensis and its main compounds with leukemia, explores the potential options of leukemia treatment, so as to provide ideas of seeking new targets of leukemia and related regulatory pathways.
