Progress of clonal evolutionary basis of FLT3-ITD-mutant acute myeloid leukemia and the effect of its different characteristics on the prognosis

VernacularTitle:急性髓系白血病FLT3-ITD突变的克隆进化基础及其不同特性对预后影响的研究进展
Author: Yuang GAO ¹ ; Heng ZHU ; Hongmei NING
Author Information

1. 解放军总医院第五医学中心血液病医学部，北京　100071
Keywords: Leukemia, myeloid, acute; fms-like tyrosine kinase 3; Mutation; Drug resistance
From: Journal of Leukemia & Lymphoma 2023;32(9):569-572
CountryChina
Language:Chinese
Abstract: The incidence of FLT3-internal tandem duplication (ITD) mutation in acute myeloid leukemia (AML) is approximately 20%-30% and FLT3-ITD mutation generally indicates a poor prognosis. Although FLT3 inhibitors have greatly improved the efficacy of AML patients with this type of AML, relapse and drug-resistance increasingly become prominent. ITD mutations lead to dimerization and continuous self-activation of FLT3 in the absence of ligands, and cause non-ligand-dependent phosphorylation. Different characteristics of ITD, including allele ratio, length, insertion site, wild-type mutation content and co-mutated genes, could affect the prognosis of patients. The underlying mechanism of these factors has an important guiding significance for clinical prognosis, drug application and treatment strategy.