Progress in the pathogenesis and the potential treatment targets of EVI1 gene positive acute myeloid leukemia

VernacularTitle:EVI1基因阳性的急性髓系白血病发病机制及潜在治疗靶点的研究进展
Author: Xiaohang MA ¹ ; Xiaosu ZHAO
Author Information

1. 北京大学人民医院　北京大学血液病研究所　国家血液系统疾病临床医学研究中心　造血干细胞移植治疗血液病北京市重点实验室，北京　100044
Keywords: Leukemia, myeloid, acute; Proto-oncogenes; EVI1 gene
From: Journal of Leukemia & Lymphoma 2023;32(9):561-565
CountryChina
Language:Chinese
Abstract: Proto-oncogene EVI1 plays an important role in the development of acute myeloid leukemia (AML). AML with EVI1 positive is characterized by abnormal high expression of EVI1 and poor prognosis. The pathogenesis of AML with EVI1 positive has been extensively studied, and the findings suggested that EVI1 can encode a zinc-finger protein that can bind to a variety of DNA. And EVI1 is closely related to the apoptosis, differentiation, proliferation and chemotherapeutic resistance of AML cells. Additionally, with the prevalent use of next-generation sequencing, a number of comutation genes and downstream target genes of AML with EVI1 positive have been discovered. The paper reviews the pathogenesis of AML caused by EVI1 and the potential treatment targets.