Research progress in pathogenesis and treatment of gastrointestinal motility disorders in Parkinson's disease
10.13481/j.1671-587X.20240135
- VernacularTitle:帕金森病胃肠动力障碍发病机制和治疗的研究进展
- Author:
Can ZHANG
1
;
Yan CHEN
Author Information
1. 滨州医学院附属医院消化内科,山东 滨州 256603
- Keywords:
Parkinson's disease;
Gastrointestinal motility disorder;
Enteric nervous system;
Gut microbiota
- From:
Journal of Jilin University(Medicine Edition)
2024;50(1):280-287
- CountryChina
- Language:Chinese
-
Abstract:
The gastrointestinal motility disorder of the patients with Parkinson's disease(PD)occurs in the early stages of this disease,even before the onset of motor symptoms.The gastrointestinal motility disorder is one type of gastrointestinal dysfunction,not only affect the absorption of medication,exacerbating the progression of PD,but also severely impact the quality of life of the patients.Therefore,it is essential to find new therapeutic targets to alleviate PD-induced gastrointestinal dysmotility in order to improve the progression of the disease and the quality of life of the patients.The gastrointestinal motility function is highly dependent on the health of the gut and central nervous regulating the gastrointestinal movements.A healthy gut is closely related to the integrity of the intestinal barrier,gut microbiota,neuroinflammation,and the normal function of enteric neurons responsible for the contraction and relaxation of the gastrointestinal tract.The gut function of the PD patients is compromised to some extent.This review summarizes the effects of the enteric nervous system,central nervous system,and gut microbiota on the development of gastrointestinal motility disorder of the PD patients;it also outlines the current therapeutic methods available and their limitations,with the aim of providing the new insights into the treatment of gastrointestinal motility disorder of the PD patients.
