Corticosteroid-associated changes resembling a demyelinating brain lesion in Diffuse Large B-cell Lymphoma (DLBCL): A case report
https://doi.org/10.21141/PJP.2021.14
- Author:
Gio Earnest de la Cruz
1
;
Justine Alessandra Uy
1
Author Information
1. Department of Laboratory Medicine and Pathology, The Medical City, Pasig City, Philippines
- Publication Type:Journal Article
- Keywords:
Diffuse large B-cell
- MeSH:
Adrenal Cortex Hormones;
Demyelinating Diseases;
Lymphoma
- From:
Philippine Journal of Pathology
2021;6(2):41-46
- CountryPhilippines
- Language:English
-
Abstract:
Biopsies of suspected lymphoma cases with history of pre-biopsy corticosteroid therapy present several diagnostic issues, such as the inability to demonstrate the neoplastic hematolymphoid cells, the similarity of post-corticosteroid changes with inflammatory demyelinating lesions, and the possibility of a demyelinating lesion preceding a central nervous system lymphoma. This report presents the case of a 51-year-old immunocompetent male with a solitary callosal mass, with immunomorphologic features suggestive of a demyelinating lesion on initial biopsy, and upon re-biopsy after three months revealed a diffuse large B-cell lymphoma. Awareness of these issues in post-corticosteroid stereotactic biopsy specimens, together with adequate clinical and radiologic data, is important for proper diagnosis and further therapeutic guidance.
- Full text:44 pjp.pdf
