Research progress on the relationship between cognitive function and oxidative stress indicators in elderly patients with Alzheimer's disease
10.3969/j.issn.1006-2483.2024.03.029
- VernacularTitle:老年阿尔兹海默症患者认知功能与氧化应激指标关系的研究进展
- Author:
Shaomin CHEN
1
;
Tingting ZHANG
2
Author Information
1. Center of Gerontology and Geriatrics , West China Hospital Sichuan University , Sichuan University ,Chengdu , Sichuan 610000 , China
2. Department of Gastroenterology , West China Hospital No.4, Sichuan University , Chengdu , Sichuan 610000 , China
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Oxidative stress;
Aβ protein;
Tau protein;
Free radicals
- From:
Journal of Public Health and Preventive Medicine
2024;35(3):123-127
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer' s disease (AD) is a neurodegenerative disease that progresses with age and is clinically characterized by cognitive impairment, memory decline, mental symptoms and behavioral disorders. Oxidative stress emerges when an imbalance exists between the generation of free radicals and the antioxidant capacity to scavenge them in the body, and the resulting oxidative injury is closely related to the occurrence of AD. Oxidative stress leads to the mass production of free radicals, which increases the oxidation of macromolecules of nerve cells, the aggregation of β amyloid (Aβ) and the excessive phosphorylation of tau protein and forms the neurofibrillary tangles, thereby inducing apoptosis of nerve tissue cells. In addition, a large number of free radicals can also cause brain inflammatory response and aggravate nerve tissue injury. This paper mainly reviews the pathogenesis of AD and its relationship with oxidative stress, aiming to provide ideas for clinical research.
