Epidemiological characteristics of childhood liver cancer in China in 2006-2017
10.3969/j.issn.1006-2483.2024.03.015
- VernacularTitle:2006—2017年中国儿童肝癌的流行特征分析
- Author:
Xiangping TANG
1
;
Mi LUO
1
;
Yongxiang YI
2
Author Information
1. School of Public Health , Nanjing Medical University , Nanjing , Jiangsu 211166 , China
2. School of Public Health , Nanjing Medical University , Nanjing , Jiangsu 211166 , China;Department of Hepatobiliary Surgery, Nanjing Second Hospital , Nanjing , Jiangsu 210003, China
- Publication Type:Journal Article
- Keywords:
Child;
Liver cancer;
Joinpoint regression;
Epidemiology
- From:
Journal of Public Health and Preventive Medicine
2024;35(3):63-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the epidemiological characteristics of liver cancer in Chinese children from 2006-2017, and to explore the correlation between hepatitis B and liver cancer in Children. Methods The data of childhood liver cancer from 2006 to 2017 were collected from the Chinese Cancer Registry Annual Report. Joinpoint regression program was used to analyze the trends of standardized incidence. Analysis was conducted to determine the distributions of incidence by region, sex and age group. The data of hepatitis B were collected from China Public Health Science Data Center. Pearson correlation was used to explore the incidence correlation between hepatitis B and liver cancer. Results From 2006 to 2017, the standardized incidence rate of childhood liver cancer in China showed a downward trend before 2010, and then remained relatively stable (AAPC=-5.09%，95%CI:-13.22%~3.80%，P=0.253). The standardized incidence rate of liver cancer showed a decreased trend in urban children (AAPC=-3.52%，95%CI:-6.82%~-0.10%，P=0.045), while the standardized incidence rate was on an upward trend in rural children (AAPC=4.95%，95%CI:1.40%~8.63%，P=0.011). The incidence rates of liver cancer were higher in urban children than in rural children (ｚ=-4.071， P<0.001), in boys than in girls (ｚ=-2.425， P=0.015), and in children of the 0~4 age group than in children of the 5~9 and 10~14 age groups (H=22.285, P<0.001). The incidence rates of both hepatitis B and liver cancer showed a downward trend from 2006 to 2017， and there was a significant correlation（r=0.775，95%CI:0.319~0.927，P=0.005). Conclusion From 2006 to 2017, the incidence of liver cancer in Chinese children showed a decreased trend with significant differences between urban-rural areas, both sexes and age groups. Boys in urban areas and children in the 0~4 years age group should be the key targets for prevention and control in the future.
