The Key Role of Interleukin-17A/Interleukin-17RA in Bone Metabolism and Diseases: A Review
https://doi.org/10.21315/aos2023.1801.RV01
- Author:
Wan Khairunnisaa Wan Nor Aduni
1
;
Asma Abdullah Nurul
1
Author Information
1. School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia
- Publication Type:Review
- Keywords:
Bone disease;
bone metabolism;
inflammatory cytokine;
interleukin-17A;
interleukin-17A receptor
- From:Archives of Orofacial Sciences
2023;18(no.1):1-17
- CountryMalaysia
- Language:English
-
Abstract:
Bone metabolism requires a balance mechanism between intricate processes of bone formation
and resorption, which is affected by the essential interaction between osteoblasts and osteoclasts.
Interleukin-17 (IL-17) is a family of cytokines consisting of six isoforms: IL-17A, IL-17B, IL-17C,
IL-17D, IL-17E, and IL-17F. Among these isoforms, IL-17A has shown promising and novel roles in
the regulation of bone metabolism. IL-17A has also captivated the interest of many researchers since
its discovery because of its role as a pro-inflammatory cytokine which mediates a few inflammatory
processes. This review describes the biology of IL-17A and its receptor as well as summarises
the regulatory role of IL-17A in bone metabolism and diseases through some known pathways.
Understanding the function of IL-17A in bone metabolism may lead to the development of therapeutics
or diagnostic strategies for some bone diseases; as well as future therapy using tissue engineering and regenerative medicine approaches.
- Full text:2.2023my0009.pdf
