Research progress of ferroptosis in ocular fundus diseases
10.3980/j.issn.1672-5123.2024.5.20
- VernacularTitle:铁死亡在眼底疾病中的研究进展
- Author:
Juanying LI
1
;
Wenfang ZHANG
1
Author Information
1. Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province, China; Department of Ophthalmology, Lanzhou Chinese Medicine Hospital, Lanzhou 730030, Gansu Province, China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
fundus disease;
pathogenesis;
research progress
- From:
International Eye Science
2024;24(5):767-771
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a unique and new mode of cell death, which is driven by iron-dependent lipid peroxidation and mainly characterized by the accumulation of reactive oxygen species in cytoplasm and lipids. Ferroptosis plays an important role in the pathogenesis of many ocular fundus diseases, such as retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma and so on. The use of ferroptosis-related inhibitors or activators can regulate the course of the disease and provide new ideas for the research, prevention and treatment of ophthalmic diseases.
