The Significant Roles of Gut-lung Microbiota in Shaping and Regulating Immunity

VernacularTitle:肠-肺微生物群在免疫系统构建和调节中的重要作用
Author: Meng ZHANG ¹ ; Zhengfei YANG ²
Author Information

1. General Practice Medicine， Sun Yat-sen Memorial Hospital， Sun Yat-sen University， Guangzhou 510120， China
2. Department of Emergency Medicine， Sun Yat-sen Memorial Hospital， Sun Yat-sen University， Guangzhou 510120， China
Publication Type:Review
Keywords: gut microbiota; respiratory microbiota; gut-lung axis; immune system; immune response
From: Journal of Sun Yat-sen University(Medical Sciences) 2024;45(2):171-179
CountryChina
Language:Chinese
Abstract: The interaction between microbes and the human immune system has long been a focus in biomedical research. Next-generation sequencing has revealed that in addition to gut microbiota， the respiratory tract also harbors microbial communities， forming an interconnected network with the gut microbiota through immune cells and active factors. This review aims to explore how the gut and lung microbiota regulate immune responses， including their roles in local and systemic immune modulation. It also delineates the immunological connections along the gut-lung axis. Further elucidating the influence of microbes on the immune system holds important clinical significance for understanding diseases and exploring novel diagnostic and therapeutic strategies.