Progress in Research on Roles of Intestinal Immunoregulatory Cells in Intestinal Mucosal Homeostasis
10.3969/j.issn.1008-7125.2020.07.012
- Author:
Zhongsheng FENG
1
;
Zhanju LIU
1
;
Wei WU
1
Author Information
1. Department of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University
- Publication Type:Journal Article
- Keywords:
Gut Microbiota;
Intestinal Immunoregulatory Cells;
Intestinal Mucosal Homeostasis
- From:
Chinese Journal of Gastroenterology
2020;25(7):436-440
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal immunoregulatory cells are a variety of cells with immunosuppressive function, including regulatory T cells, regulatory B cells, regulatory dendritic cells, M2 macrophages, innate lymphoid cells, fibroblast reticular cells, etc., which are the keys for maintaining intestinal immune tolerance and mucosal homeostasis. Gut microbiota is closely related with immunoregulatory cells. It is shown that gut microbiota and their metabolites maintain the normal function of immunoregulatory cells through activating pattern recognition receptor signaling pathway. This article reviewed the roles of intestinal immunoregulatory cell in maintenance of intestinal mucosal homeostasis.
