Association Between TLR2, TLR4 and NOD2/CARD15 Gene Polymorphisms and Ulcerative Colitis: A Meta-analysis
10.3969/j.issn.1008-7125.2021.02.004
- Author:
Yu XIA
1
;
Jian LI
1
;
Hongliang GAO
1
Author Information
1. The Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University
- Publication Type:Journal Article
- Keywords:
Colitis, Ulcerative;
Gene Polymorphisms;
Meta-Analysis;
NOD2/CARD15;
Toll-Like Receptors
- From:
Chinese Journal of Gastroenterology
2021;26(2):82-90
- CountryChina
- Language:Chinese
-
Abstract:
Background: The prevalence rate of ulcerative colitis (UC) in China has increased significantly in recent years, and Toll-like receptor 2 (TLR2), TLR4 and NOD2/CARD15 may be closely related to the development of UC. Aims: To explore the influence of TLR2, TLR4 and NOD2/CARD15 gene polymorphisms on the pathogenesis of UC. Methods: Studies on correlation of TLR2, TLR4 and NOD2/CARD15 gene polymorphisms with UC were retrieved from PubMed, CBM, CNKI, Wanfang, VIP databases. Literatures were enrolled according to the inclusion and exclusion criteria, and the quality was evaluated and data were extracted. RevMan 5.3 software was used to conducted meta-analysis. Results: Fifteen eligible articles were included. Meta-analysis showed that TLR2 Arg753Gln gene polymorphism was not associated with risk of UC (P>0.05). Except the recessive model, TLR4 Asp299Gly gene polymorphism could increase the risk of UC (P<0.05). The overdominant model of TLR4 Thr399Ile gene could increase the risk of UC (P<0.05), but not the dominant model and recessive model (P>0.05). No significant association between NOD2/CARD15 (Arg702Trp, Gly908Arg and Leu1007fsinsC) gene polymorphism and UC was found (P>0.05). Conclusions: Existing evidence shows that TLR4 (Asp299Gly, Thr399Ile) gene polymorphisms are associated with an increased risk of UC, however, NOD2/CARD15 (Arg702Trp, Gly908Arg and Leu1007fsinsC) and TLR2 (Arg753Gln) gene polymorphisms are not associated with UC.
