Progress in Research on Helicobacter pylori Thioredoxin
10.3969/j.issn.1008-7125.2022.05.008
- Author:
Xin GUAN
1
;
Jing NING
1
;
Jing ZHANG
1
;
Shigang DING
1
Author Information
1. Department of Gastroenterology, Beijing Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases, Peking University Third Hospital
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Stomach Neoplasms;
Thioredoxins
- From:
Chinese Journal of Gastroenterology
2023;27(5):311-315
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori (Hp) infection is one of the main causes of gastric cancer. The virulence factors of Hp, cytotoxin⁃associated gene A (CagA) and vacuolating cytotoxin A (VacA), are closely related to the pathogenicity of Hp in European and American countries. However, the positivity rate of CagA is as high as 90% in East Asian countries, indicating that the above⁃mentioned virulence factors could not fully explain the differences in pathogenicity of Hp, and other pathogenic factors might be speculated. In our previous studies, thioredoxin⁃1 (Trx1) was found to be a virulence factor of highly pathogenic Hp, and a series of studies were conducted on Hp Trx1 in cytology, zoology and human histology. This article reviewed the progress in research on Hp Trx1.
