The Molecular Mechanism of SIRT1-Catalysed Deacetylation on Non-Histone Proteins and Its Impact on Cell Apoptosis
10.13865/j.cnki.cjbmb.2021.03.1639
- Author:
Han-Zhi BEN
1
;
Bing-Quan QIU
1
;
Yang YANG
1
Author Information
1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University
- Publication Type:Journal Article
- Keywords:
cell apoptosis;
deacetylation;
silent information regulator factor 2-related enzyme 1 (SIRT1)
- From:
Chinese Journal of Biochemistry and Molecular Biology
2021;37(10):1281-1289
- CountryChina
- Language:Chinese
-
Abstract:
Sirtuins belongs to the class III family of histone deacetylases (HDAC), which is a mammalian homolog of the yeast silencing information regulator Sir2. Silent information regulator factor 2-related enzyme 1 (SIRT1) is the most well studied family member of Sirtuins. Distributed mainly in the nucleus and cytoplasm, SIRT1 is involved in various intracellular biological processes, including DNA damage repair, gene transcription, energy metabolism, stress and apoptosis through its NAD
