Mechanism of Genetic Robustness
10.13865/j.cnki.cjbmb.2023.01.1460
- Author:
Yi-Hang XIANG
1
;
Huan HUANG
1
;
Chen-Sheng LIN
1
Author Information
1. Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University
- Publication Type:Journal Article
- Keywords:
gene function;
genetic compensation reaction;
genetic redundancy;
genetic robustness;
Upf3a
- From:
Chinese Journal of Biochemistry and Molecular Biology
2023;39(9):1229-1237
- CountryChina
- Language:Chinese
-
Abstract:
Genetic robustness refers to the fact that an organism has a buffer system that can maintain normal development, even if the existence of genetic mutations during biological development. Previous research on the underlying mechanism of genetic robustness mainly involves in genetic redundancy and distributed robustness, both of which are triggered at the protein level. Recently, a new genetic compensation response (GCR) mechanism has been discovered in zebrafish, which occurs in knockout rather than knockdown individuals and is triggered upstream of protein feedback regulation. Since there are many concepts related to genetic robustness, this review attempts to clarify these concepts from the types of compensation genes and triggering modes. Additionally, we aim to understand the latest discovered GCR mechanism and look forward to studying the function of specific genes based on functional compensation mechanisms.
