Calcium/Calmodulin Mediates Cardiomyocyte Ferroptosis in Myocardial Infarction Through Iron Overload
10.13865/j.cnki.cjbmb.2023.06.1587
- Author:
Zhong-Hao ZHAO
1
;
Lin SONG
1
;
Fu-Qing YANG
1
;
Jian-Xun WANG
1
Author Information
1. School of Basic Medical Sciences, Qingdao University
- Publication Type:Journal Article
- Keywords:
Ca;
calmodulin(CaM);
ferroptosis;
L-type voltage-dependent calcium channel(LVDCC);
myocardial infarction(MI)
- From:
Chinese Journal of Biochemistry and Molecular Biology
2023;39(7):1023-1035
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction(MI), an acute coronary syndrome that poses a serious risk to human health, involves multiple pathophysiological processes, including calcium overload. Existing therapeutic approaches and preventive measures have limitations and cannot effectively repair myocardial cells with poor regenerative potential. Exploring multiple programmed modes of cardiomyocyte death could help find potential targets for the treatment of myocardial infarction, and the potential role of ferroptosis as a novel mode of cell death in myocardial infarction has attracted great attention. The aim of this study was to investigate whether Ca
