Six-week Aerobic Exercise Improves Oxidative Damage of Skeletal Muscles and Promotes Myokine Production in Atherosclerotic Mice
10.13865/j.cnki.cjbmb.2023.03.1639
- Author:
Yang-Wen-Jie WANG
1
;
Jessica LAVIER
2
;
Grégoire P MILLET
2
;
Yang-Wen-Jie WANG
3
;
Wei-Cheng HUA
3
;
Rui-Qi WANG
3
;
Ying ZHANG
3
Author Information
1. Key Laboratory of Exercise and Physical Fitness, the Ministry of Education
2. Institute of Sports Science, University of Lausanne
3. School of Kinesiology, Beijing Sport University
- Publication Type:Journal Article
- Keywords:
Key words atherosclerosis;
myokine;
oxidative damage;
skeletal muscle
- From:
Chinese Journal of Biochemistry and Molecular Biology
2023;39(6):857-869
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis involving peripheral arteries can cause skeletal muscle lesions, in which oxidative damage is an important manifestation, and atherosclerosis also reduces the production and secretion of beneficial myokines. Irisin, musclin and β-aminoisobutyric acid (BAIBA) are thought to be involved in improving atherosclerosis. However, the molecular mechanism of atherosclerosis-induced skeletal muscle lesions and the effects of aerobic exercise training on the oxidative damage of skeletal muscle and myokine production remain unclear. In this study, apolipoprotein E knockout (ApoE
