Outcomes of frozen-thawed embryo transfer cycles of progestin-primed ovarian stimulation protocol compared with other three ovulation hyperstimulation protocols
10.16098/j.issn.0529-1356.2021.02.019
- Author:
Jian-Hua LI
1
;
Ting-Ting JIAO
1
;
Jian-Ve WANG
1
;
Chang-Shan LI
1
;
Pan DONG
1
;
Shui-Wen ZHANG
1
;
Xi CHEN
2
Author Information
1. Center of Reproductive Medicine and Genetics, The Seventh Medical Center, Chinese People's Liberation Army General Hospital
2. Center for Reproductive Medicine, Peking University Second Hospital
- Publication Type:Journal Article
- Keywords:
Clinical pregnancy rate;
Controlled ovarian hyperstimulation;
Female;
Frozen-thawed embryo transfer;
In vitro fertilization;
Intracytoplasmic sperm injection;
Progestin primed ovarian stimulation
- From:
Acta Anatomica Sinica
2021;52(2):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical outcomes of progestin primed ovarian stimulation (PPOS) compared with the other three different controlled ovarian hyperstimulation (COH) protocols in fresh embryo transfer (ET) and frozen-thawed embryo transfer (FET) cycles. Methods A total of 430 oocyte pick-up cycles and 272 FET cycles were retrospectively analyzed. Number of oocytes retrieved, laboratory indexes and pregnancy outcome of FET were compared. Results The mean oocytes retrieved (11.1±7.3), fertilization rate (85.6%), cleavage rate (95.1%) and excellent embryo rate (20.2%) as well as transplantable embryo rate (4. 5 ±3.1) of the PPOS group did not show significant differences compared with the other 3 subgroups (all P<0.05) in fresh cycle. As for pregnancy outcomes in FET cycles, no statistically significant differences were observed among the four groups in embryo implantation rate (26.2%), clinical pregnancy rate (63.0%) and abortion rate (11.8%) (all P<0.05). However, embryo implantation rate, clinical pregnancy rate was higher in PPOS group compared with the other groups. Conclusion Compared with the other three ovulation stimulation programme, PPOS might be used as a new alternative for controlled ovulation stimulation protocols.
